Date of Graduation

Spring 3-2011

Degree Type

Capstone Project

Degree Name

Master of Science in Physician Assistant Studies

First Advisor

Torry Cobb

Abstract

Background: Development of colorectal cancer (CRC) has been linked to several lifestyle factors including alcohol consumption. Less well understood is the relationship of wine consumption to the development of CRC. Among the purported health benefits of wine consumption there is evidence of in vitro suppression of colon cancer cells, but these studies lack clinical validation. This systematic review aims to determine the clinical outcomes of wine consumption on the development of CRC and use the GRADE system to evaluate the available evidence regarding this outcome.

Method: An exhaustive search was performed of available medical literature from 2000 to the present for studies that investigated wine consumption and diagnosis of colorectal cancer. The reviewed studies were examined for quantities of wine consumed and trends in colon cancer and rectal cancer incidence.

Results: The examination of the three studies in this review failed to find consensus in the relationship between wine consumption and colorectal cancer. Both protective and deleterious effects are suggested, though these relationships were most often not statistically significant.

Conclusion: Due to inconsistent relationships between studies, no confidence can be placed in a recommendation for or against drinking wine as a means of preventing CRC. Evaluation of the evidence reviewed here using the GRADE system indicates that future studies will likely improve knowledge about whatever relationships between wine consumption and CRC may exist.

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