Off-campus Pacific University users: To download campus access theses and dissertations, please log into our proxy server with your PUNet ID and password.
Non-Pacific University users: Please talk to your librarian about requesting this thesis or dissertation through interlibrary loan.
Theses or dissertations that have a specific embargo period indicated below will not be available to anyone until the date indicated.
Date of Graduation
Capstone Project (On-Campus Access Only)
Master of Science in Physician Assistant Studies
Latha Reddy MS, PA-C
Jonathon W. Gietzen MS PA-C
INTRODUCTION: Idiopathic thrombocytopenia purpura in adults has a greater likelihood of becoming refractory compared with children even after treatment. For years, this disease has been treated with immunosuppressives, particularly prednisone. However, new treatment options are emerging with better efficacy and fewer side effects.
METHODS: The focus of this study was to review the current literature for the la.st 10 years on all studies pertaining to the first . line treatment in new onset adult rTP, by comparing the long term completeremission rates. The five treatments reviewed included prednisone, high dose methylprednisolone (HDMP), high dose dexamethasone (HDD), intravenous immunoglobulin (IVIg), anti D or a combination of these.
RESULTS: Of the 6 studies published, high-dose dexamethasone, when given at 40mg/kg/day for four days every 14 days for a total of four cycles, has the best overall efficacy at maintaining complete remission at 6 months after treatment was discontinued.
CONCLUSION: High dose dexamethasone is currently the most effective first line therapy for new onset ITP in adults. However, further randomized trials and longer term studies are needed to better substantiate its use and/or the use of the other first line therapies.
Radel, Matthew A., "The Prevailing Treatments in New Onset Idiopathic Thrombocytopenic Purpura in Adults" (2007). School of Physician Assistant Studies. 6.