Faculty Scholarship (PHRM)
 

Title

The protective effect of thymoquinone, an anti-oxidant and anti­-inflammatory agent, against renal injury: A review

Document Type

Article

Publication/Creation/Presentation Date

2009

Journal

Saudi Journal of Kidney Diseases and Transplantation

Volume

20

Issue

5

Disciplines

Pharmacy and Pharmaceutical Sciences

Abstract

Thymoquinone (TQ), 2-Isopropyl-5-methyl-1, 4-benzoquinone, is one of the most active ingredients of Nigella Sativa seeds. TQ has a variety of beneficial properties including anti­oxidative and anti-inflammatory activities. Studies have provided original observations on the role of oxidative stress and inflammation in the development of renal diseases such as glomerulo­nephritis and drug-induced nephrotoxicity. The renoprotective effects of TQ have been demons­trated in animal models. Also, TQ has been used successfully in treating allergic diseases in humans. The aim of this review is to highlight the importance of reactive oxygen species in renal pathophysiology and the intriguing possibility for a role of TQ in the prevention of and/or protection from renal injury in humans.

Comments

© 2009, Saudi Center for Organ Transplantation. This article may also be viewed on the publisher's website.