Date of Award

12-2000

Degree Type

Thesis

Degree Name

Master of Science in Vision Science

Committee Chair

Jennifer Smythe

Abstract

Introduction: Rigid gas permeable lenses have many advantages over soft contact lenses yet due to ocular discomfort and associated period of adaptation required with this modality, many practitioners neglect to consider this option. Topical anti-inflammatory drugs(NSAIDs), including diclofenac sodium or Voltaren, have become popular among practitioners for it's analgesic, anti-inflammatory and anti-puretic effects. It has also been demonstrated that Voltaren decreases corneal sensitivity and has an anesthetic effect in healthy, unoperated human corneas, and that pretreatment with diclofenac before cataract surgery decreases post-operative inflammation. Our proposal is that the use of Voltaren post RGP dispense for one week will provide increased comfort, better tolerance and improve adaptability to RGP use.

Sub]ects/Methods: Ten subjects were enrolled, all of whom were new rigid lens wearers and free of contraindicating corneal disease. Two randomly selected groups were chosen for either the placebo or Voltaren drops. Each subject was evaluated using currently accepted fitting techniques, and at the dispense were given a manila envelope containing the masked bottle marked "A" or "B". Each subject filled out two questionnaires based on their perception of, and adaptation to, rigid lenses at four intervals: pre-fitting, after fifteen minutes post-fit, at one week and one month. Each subject was re-evaluated at these sessions as well to ensure their lenses were fitting appropriately.

Results: Statistics were run using unpaired tests for each questionnaire and significance was found, albeit in favor of the placebo group, in five categories: Long Term Wear, Comfort, Tearing, Lens Awareness and Blinking.

Discussion: Results from this study indicate that there is no statistical significance in favor of using Voltaren versus the placebo. This may have been due to a preexisting bias of those in the placebo group even though each subject was randomly assigned, as there was significance found in the Pre-Fit answers to the questions of Long Term Wear and Lens Awareness. This factor may have negatively impacted the results. Further study needs to be undertaken on this subject, using Voltaren at least three times prior to lens insertion at dispense.

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Optometry Commons

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