Date of Award

5-2007

Degree Type

Thesis

Degree Name

Master of Science in Vision Science

Committee Chair

Peter D. Bergenske

Abstract

Purpose: Silicone hydrogel lenses were initially introduced due to the advantages of increased oxygen transmissibility for continuous wear. The introduction of newer silicone hydrogel lenses however is shifting this class of contact lenses toward daily wear. This study compared the daily wear clinical performance of a silicone hydrogel with a biomimetic hydrogel lens for comfortable wearing time, end-of-the-day and overall comfort.

Methods: This was a subject- masked, bilateral cross over investigation. 40 subjects wore the two test lenses in random succession and were evaluated after 2 and 4 weeks of wear.

Results: Mean comfort score on a 0-100 visual analogue scale was 79.0 for the traditional hydrogel (Lens A), and 68.8 for the silicone hydrogel (Lens B) (two-tailed P = 0.0046). Mean comfortable wear time for the Lens A was 11.83 hours and for the Lens B 10.75 (two-tailed P = 0.0563). There were no significant differences between lens types for dynamic and static lens fit, visual acuity or subjective ratings of visual quality. Slit lamp findings were similar between lens types except for Limbal Redness, which was better for Lens Bat the 4 week point. Burning/Stinging and Dryness symptoms demonstrated a trend to lower frequency with Lens A. 68% preferred Lens A overall compared to 32% for Lens Band 0% reporting no difference. For end-of-the-day comfort, 59% preferred Lens A as compared to 24% Lens Band 17% indicating no preference.

Conclusion: Both lenses offer excellent overall clinical performance. These findings suggest that high Dklt alone is not sufficient for optimal contact lens wearing comfort and daily wear success.

Included in

Optometry Commons

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