Date of Graduation

Spring 5-1-2011

Degree Type

Capstone Project

Degree Name

Master of Science in Physician Assistant Studies

First Advisor

Torry Cobb, DHSc, MPH, PA-C

Second Advisor

Annjanette Sommers MS, PA-C


Background: The problem of obesity in the adult population requires the exploration and development of new, safe effective therapies to combat increasing girth. Implantable gastric electrical stimulation (GES) offers a novel, minimally invasive surgical approach to promote weight loss. This report utilizes the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool to review and evaluate current literature exploring GES as a safe and effective therapy for reducing obesity in adults.

Method: An exhaustive search of available medical literature was conducted in the PubMed, Medline, Evidence-Based Medicine Reviews Multifile, Web of Science, and CINHAL databases.

Results: Three studies were reviewed for the primary endpoint of percentage of excess weight loss (EWL) and secondary endpoint of device safety. GRADE results revealed moderate levels of evidence for both of these endpoints. A small subset of adult patients experienced weight loss ranging between 5-17% EWL while other patients experienced weight gain.

Conclusion: Use of a gastric electrical stimulation device fails to produce any significant weight loss in obese individuals when compared to traditional lifestyle changes of diet and exercise. Implantable GES for weight loss in obese adults is not recommended.

GES Poster.ppt (1872 kB)