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Date of Graduation


Degree Type

Capstone Project (On-Campus Access Only)

Degree Name

Master of Science in Physician Assistant Studies

First Advisor

Randy Randolph, MPAS, PA-C


Background: Foreign material is being implanted more often to enhance the outcomes of surgery. If these prostheses become infected they are difficult to treat. Two of the antibiotics used to clear these infections are vancomycin and the newer linezolid. Along with the antibiotics, the prosthesis may be debrided and salvaged, or replaced.

Method: This is a retrospective study evaluating the use of linezolid and vancomycin separately and combined in the treatment regiments for gram positive infections of implanted prosthetic devices. This study looks at the use of these medicines in two major groups. The first group includes patients with infected joint prostheses and/or other artificial devices which are managed with a two step revision arthroplasty. The second group includes patients with infected implants that have been treated without removal of the material. A test of cure assessment at six months is performed, as well as an evaluation of length of hospital stay. p

Results: 35 patients are used in this study. This study shows that there is no difference in the cure rates for those treated with vancomycin and those taking linezolid. It was also found that the length of hospital stay was not significantly different for the two groups.

Conclusion: Linezolid is an effective treatment for gram-positive infections of joint prostheses and while it does not reduce length of hospital stays it may be a valuable alternative to vancomycin.


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