Date of Graduation

Summer 8-13-2016

Degree Type

Capstone Project

Degree Name

Master of Science in Physician Assistant Studies

First Advisor

Mark Pedemonte, MD

Second Advisor

Annjanette Sommers, PA-C, MS


Background: Although providers have been using supplemental oxygen therapy in the treatment of myocardial infarction for over 100 years, there are currently no current guidelines established for the treatment of normoxic patients. Research has shown possible worsened outcomes for uncomplicated myocardial infarctions when oxygen is used; including worsened ischemic area and increased arrhythmias. The aim of this systematic review is to evaluate the research on whether or not supplemental oxygen therapy can cause increased cardiac events for patients presenting with an uncomplicated AMI.

Methods: An exhaustive search of the literature was performed using MEDLINE-Ovid, Web of Science, and ClinicalKey. Key words included myocardial infarction, oxygen, and oximetry.

Results: Out of the 16 relevant articles found, only two articles fit all inclusion and exclusion criteria. Both studies showed evidence of increase infarct size and cardiac arrhythmias with supplemental oxygen use in uncomplicated myocardial infarctions. The overall quality of evidence was found to be moderate. Further studies are needed to show the long-term morbidity and mortality.

Conclusion: The use of supplemental oxygen in an uncomplicated AMI has been shown to cause an increase in infarct size as well as increased cardiac arrhythmias and recurrent myocardial infarcts. Although there is evidence to support short term worsened cardiac events, there are currently no studies for long-term morbidity and mortality. Further research is required to determine the long-term effects of oxygen supplementation for normoxic patients with acute myocardial infarctions.