Date of Graduation

Summer 8-10-2019

Degree Type

Capstone Project

Degree Name

Master of Science in Physician Assistant Studies

Abstract

Background: Lichen sclerosus (LS) is a chronic, inflammatory tissue disease that most commonly affects adult women. The current treatment is long-term topical steroids. Platelet-rich plasma (PRP) has gained much attention as a treatment for multiple tissue disorders due to its rejuvenating qualities. The purpose of this review is to investigate PRP’s effectiveness on treating lichen sclerosus in adult women.

Methods: An Exhaustive literature search was performed using MEDLINE, TRIP, and Google Scholar and the following search terms were used “vaginal atrophy,” "lichen sclerosus," "vulvovaginal atrophy," "lichen simplex chronicus," "platelet." All studies included were within the last 5 years and of English language.

Results: The search yielded 3 articles that met criteria. All 3 articles were case studies. There was an overall trend in all 3 articles that PRP treatment improves the clinical course of LS as well as improves patients’ symptoms. However, the overall quality of the articles is very low due to limitations and high risk of bias (see Table 1). Future studies are needed to yield a higher grade of research for more definitive conclusions on this topic.

Conclusion: While the studies that investigated the effects of PRP treatment on adult women with LS had an overall positive trend, more research is needed due to the very low quality of evidence. Randomized controlled trials with larger sample sizes, blinding, and adequate follow-up times are needed to better determine the effects of PRP on LS in adult women. Only then will medical professionals have a better idea if PRP can replace topical corticosteroids as the gold standard for treatment.

Keywords: Lichen sclerosus, vaginal atrophy, vulvovaginal atrophy, lichen simplex chronicus, platelet.

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