Date of Graduation

Summer 8-10-2019

Degree Type

Capstone Project

Degree Name

Master of Science in Physician Assistant Studies

Abstract

Background: Heart Failure is a growing clinical syndrome that results in major impacts on patients and the medical system. Previously, therapy has improved symptoms while leaving the patient disabled in the later stages. Renal denervation (RDN) is a procedure that is being researched for its effect on improving the condition of heart failure along with its symptoms and increasing exercise tolerance in patients.

Methods: Exhaustive search of available medical literature using MEDLINE via PubMed, CINAHL, Web of Science and Google Scholar using the keywords renal denervation, heart failure and exercise tolerance. The studies that fit the eligibility criteria were appraised with the GRADE system for quality.

Results: Three studies were considered after the exclusion criteria were applied. The first study assessing RDN for patients with heart failure was terminated early due to low recruitment. Another study by the same group showed that RDN was a promising treatment needing more research and clinical evidence. The most recent study, an RCT, found that RDN safely improved cardiac function and exercise tolerance in patients with heart failure.

Conclusion: RDN does improve exercise tolerance in patients with heart failure. More clinical evidence is needed to place this treatment in common practice but RDN should be considered when reviewing options for patients with heart failure.

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