Linkage of a possible disease susceptibility gene for keratoconus with the HLA system was studied in 2 families where more than one member of each family had the disease. HLA haplotypes were obtained from all family members, both with and without keratoconus and compared among family members and between families. Preliminary data indicates that a genetic linkage of a disease susceptibility gene to the HLA system is not present in the disease keratoconus.
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