This study compares the effects of three sympathomimetic agents used in over-the-counter ocular decongestants, tetrahydrozoline, phenylephrine and naphazoline on intraocular pressure, anterior chamber angle and pupil diameter in normal healthy adult eyes. Both short term effects, monitored at 15 minutes, 30 minutes and 45 minutes following initial drop instillation, and long term effects measured for 96 hours during habitual use were studied. Only one product, Visine, which contains tetrahydrozoline, produced a significant change in the measured parameters. Visine lowered the intraocular pressure an average of 1.9 mmHg thirty minutes after instillation.
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