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Safety and Efficacy of Colchicine in the Treatment of Recurrent Aphthous Stomatitis

1 April 2011


Background: Recurrent aphthous stomatitis is among the most common oral lesions observed by physicians. Definitive treatment has been difficult considering its unknown etiology; however, proposed immunologic factors have led to the use of immunosuppressive agents. Colchicine has been shown to have an effect on all types of RAS through its anti-inflammatory action by way of suppressing phagocytosis and migration of leukocytes, but its safety and efficacy have only been addressed in a few small studies.

Method: An exhaustive search of available medical literature was conducted, from 2000 to present, using CINHAL, Cochrane Systematic Reviews, PubMed, Medline-OVID, and MD Consult database. Quality of evidence in each article was assessed using GRADE.

Results: Three studies met criteria for this systematic review. A double blind, randomized-controlled trial, demonstrated reduction in pain and burning sensation from baseline score ± SD in colchicine (7.92 ± 2.39 score, p

Conclusion: Based on this systematic review of literature and use of GRADE, there is moderate evidence showing colchicine is a safe and effective treatment in pain reduction and relapse prevention for patients with recurrent aphthous stomatitis. However, further research is likely to have an impact on estimate of benefit and risk.

Keywords: Colchicine, recurrent aphthous stomatitis.


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