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Thesis

Evaluating nerve fiber layer changes in diabetic subjects using the GDxVCC

1 May 2005

Abstract

Purpose: Scanning laser polarimetry using the GDxVCC was conducted on diabetic and non-diabetic subjects to determine if RNFL (retinal nerve fiber layer) thickness differed between these two cohort groups. Design: Prospective, comparative case series, pilot study Subjects: Forty-four diabetic and forty-two non-diabetic subjects.

Methods: Subjects had a one-time office visit, consisting of visual acuities, pupil assessment, angle assessment, intraocular pressures, a GDxVCC scan, and a full fundus exam to determine if there were clinical findings of retinopathy present. Retinopathy was staged using the ETDRS (Early Treatment Diabetic Retinopathy Study) protocol.

Conclusion: The RNFL (retinal nerve fiber layer) in diabetic subjects was found to be statistically significantly thinner than the RNFL in non-diabetic subjects, but additional data collection is needed before conclusive results can be obtained.


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