This was a cluster-randomized trial assessing feasibility, acceptability, initial efficacy, and exploratory mediators and moderators of a trauma-integrated adaptation of Mindfulness-Based Relapse Prevention (MBRP) for women with dually diagnosed PTSD and Substance Use Disorder (SUD). Women were randomized to participate in either Trauma-Integrated MBRP (TI-MBRP) or standard MBRP. Pre-, post-, and one-month follow-up assessments were completed. Results indicated that TIMBRP was feasible and acceptable for dually diagnosed women receiving SUD treatment. Additionally, TI-MBRP demonstrated initial efficacy in primary outcomes; interaction effects were observed in trauma symptom severity between groups. Further, mediating effects of psychological flexibility, and moderating effects of mindfulness and resilience were observed on the relationship between trauma symptom severity and substance craving.
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