Lysozyme previously has been shown to be reduced from normal levels following ocular pathology, irritation, or hard contact lens wear. Utilizing a spectropholometric method to measure the activity of human tear lysozyme against a living bacterial substrate, we compared the activities in a group of new soft contact lens wearers during an adaptation period of two weeks with activities from a group of non-contact lens wearers. We found no significant difference in the tear lysozyme activities between the two groups but found a stabilizing effect of soft lens wear upon random activity variations.
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